Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT) a clinical-stage biotechnology company developing PV-10 as the first small molecule oncolytic immunotherapy for solid tumor cancers, today announced that the Japan Patent Office had granted and the European Patent Office had allowed the Company’s patent application for the combination of PV-10 with systemic immunomodulatory therapy (i.e., immune checkpoint inhibition). Pfizer, Inc. is a co-assignee on the award and allowance.

The JPO patent and EPO patent allowance are related to U.S. patent (USP) 9,839,688, “Combination of rose bengal and systemic immunomodulative therapies for enhanced treatment of cancer,” which was awarded by the United States Patent and Trademark Office (USPTO) in December 2017. USP 9,839,688 is one of the continuations of the Company’s foundational cancer combination therapy patent, USP 9,107,887, which was awarded by the USPTO in August 2015.

Provectus’ patent portfolio provides global intellectual property protection into the 2030s for the synthesis and use of PV-10 and other halogenated xanthene-based therapeutics as monotherapies and part of combination therapies for cancer.